Irwin Rose
| Irwin A. Rose | |
 Irwin Rose (left)
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| Born | June 16, 1926 |
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| Nationality | United States |
| Fields | Biology |
| Alma mater | University of Chicago |
| Known for | Ubiquitin-mediated protein degradation |
| Notable awards | Nobel Prize in Chemistry (2004) |
Irwin A. Rose (born 16 July 1926) is an American biologist. Along with Aaron Ciechanover and Avram Hershko, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation.
Rose attended Washington State University for one year prior to serving in the Navy during WWII. Upon returning from the war he received his B.S. in 1948 and his Ph.D. in biochemistry in 1952, both from the University of Chicago. He is currently a distinguished professor-in-residence at the Department of Physiology and Biophysics of the College of Medicine at the University of California, Irvine.
Irwin (Ernie) trained several postdoctoral fellows while at the Fox Chase Cancer Center in Philadelphia, where the groundbreaking Ub work was done. These included Art Haas, the first to see Ubiquitin chains, Keith Wilkinson, the one to first identify APF-1 as Ubiquitin, and Cecile Pickart, a world class enzymologist in many parts of the Ub system.
Ernie would frequently tour the lab, with a harmonica, when Avram and Aaron were there working in the summer with Keith and Art.
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Publications
- Hershko, A., Ciechanover, A., and Rose, I.A. (1979) "Resolution of the ATP-dependent proteolytic system from reticulocytes: A component that interacts with ATP". Proc. Natl. Acad. Sci. USA 76, pp. 3107-3110.
- Hershko, A., Ciechanover, A., Heller, H., Haas, A.L., and Rose I.A. (1980) "Proposed role of ATP in protein breakdown: Conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis". Proc. Natl. Acad. Sci. USA 77, pp. 1783-1786.
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See also
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References
- Rose, Irwin (2005), “Early work on the ubiquitin proteasome system, an interview with Irwin Rose. Interview by CDD.”, Cell Death Differ. 12 (9): 1162-6, PMID 16094392, doi:10.1038/sj.cdd.4401700, <http://www.ncbi.nlm.nih.gov/pubmed/16094392>
- “Nobel Prize in Chemistry, 2004. Aaron Ciechanover, Avram Hershko and Irwin Rose.”, Indian J. Physiol. Pharmacol. 49 (1): 121, 2005, PMID 15881872, <http://www.ncbi.nlm.nih.gov/pubmed/15881872>
- Latonen, Leena & Laiho, Marikki (2004), “Nobel prize in chemistry goes to three persons with a key role in revealing the ubiquitin-mediated protein degradation pathway”, Duodecim; lääketieteellinen aikakauskirja 120 (24): 2868-71, PMID 15700582, <http://www.ncbi.nlm.nih.gov/pubmed/15700582>
- Goldberg, Alfred L (2005), “Nobel committee tags ubiquitin for distinction.”, Neuron 45 (3): 339-44, 2005 Feb 3, PMID 15694320, doi:10.1016/j.neuron.2005.01.019, <http://www.ncbi.nlm.nih.gov/pubmed/15694320>
- Neefjes, J; Groothuis, T A M & Dantuma, N P (2004), “The 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation”, Nederlands tijdschrift voor geneeskunde 148 (52): 2579-82, 2004 Dec 25, PMID 15646859, <http://www.ncbi.nlm.nih.gov/pubmed/15646859>
- Vogel, Gretchen (2004), “Nobel Prizes. Gold medal from cellular trash.”, Science 306 (5695): 400-1, 2004 Oct 15, PMID 15550643, doi:10.1126/science.306.5695.400b, <http://www.ncbi.nlm.nih.gov/pubmed/15550643>
- Giles, Jim (2004), “Chemistry Nobel for trio who revealed molecular death-tag.”, Nature 431 (7010): 729, 2004 Oct 14, PMID 15483574, doi:10.1038/431729a, <http://www.ncbi.nlm.nih.gov/pubmed/15483574>
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