Aaron Ciechanover (אהרן צ'חנובר) (born October 1, 1947) is an Israeli biologist, and a 2004 Nobel laureate in Chemistry for his discovery with Avram Hershko and Irwin Rose, of ubiquitin-mediated protein degradation. He also received in 2000 the Albert Lasker Award for Basic Medical Research and the Israel Prize for Biological Research in 2003.

Born in Haifa, Israel, Ciechanover received his Master of Science degree in 1971 and his M.D. in 1974 from the Hadassah Medical School of the Hebrew University in Jerusalem. He received his doctorate in biochemistry in 1982 from the Technion (the Israel Institute of Technology), in Haifa. He is currently a Technion Distinguished Research Professor in the Ruth and Bruce Rappaport Faculty of Medicine and Research Institute at the Technion.

Ciechanover is a member of the Israel Academy of Sciences and Humanities, the Pontifical Academy of Sciences, and the United States National Academy of Sciences (Foreign Associate).

His family came to Israel from Poland before the Second World War.

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Publications

1.Ciechanover, A., Hod, Y. and Hershko, A. (1978). A Heat-stable Polypeptide Component of an ATP-dependent Proteolytic System from Reticulocytes. Biochem. Biophys. Res. Commun. 81, 1100-1105.

2.Ciechanover, A., Heller, H., Elias, S., Haas, A.L. and Hershko, A. (1980). ATP-dependent Conjugation of Reticulocyte Proteins with the Polypeptide Required for Protein Degradation. Proc. Natl. Acad. Sci. USA 77, 1365-1368.

3. Hershko, A. and Ciechanover, A. (1982). Mechanisms of intracellular protein breakdown. Annu. Rev. Biochem. 51, 335-364.

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External links

• Nobel citation
• Website at the Technion
• Aaron Ciechanover and Avram Hershko 2004 Nobel in Chemistry - A web article

v • d • e Nobel Laureates in Chemistry William Knowles / Ryoji Noyori / K. Barry Sharpless (2001) · John B. Fenn / Koichi Tanaka / Kurt Wüthrich (2002) · Peter Agre / Roderick MacKinnon (2003) · Aaron Ciechanover / Avram Hershko / Irwin Rose (2004) · Robert H. Grubbs / Richard R. Schrock / Yves Chauvin (2005) · Roger D. Kornberg (2006) · Gerhard Ertl (2007) Complete roster · 1901–1925 · 1926–1950 · 1951–1975 · 1976–2000 · 2001–present

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